Prof. Jakub Hort, MD (CZ)

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Head of Memory clinic, Dept. of Neurology, 2nd Medical School, Charles University, Director of Neuro 2 program (Alzheimer disease) at International Clinical Research Center (ICRC), Brno

Business address: Department of Neurology 2nd Medical School Charles University V Úvalu 84 150 18 Praha 5 Czech Republic Tel.: +42022443 6860 Fax: +420224436820 E-mail: jakub.hort (at) sez­nam.cz

Education: 19988–1994 2nd Medical School, Charles University April 1997 1st degree specialization in Neurology 1994–1998 Postdoctoral studies in Biomedicine – Neurosciences March 1998 State examination in Neurosciences May 2000 2nd degree specialization in Neurology

Employment: since 2001 Head of Memory clinic, Dept. of Neurology, 2nd Medical School, Charles University since 2011 director of Neuro 2 program (Alzheimer disease) at International Clinical Research Center (ICRC), Brno, Czech republic – joint project of European Union, Czech republic and Mayo clinic, Rochester, USA since 2004 Chairman of the Section on Cognitive Neurology, Czech Neurological Society (re-elected 2009) 1998–2008 Assistant professor at Dept. of Physiology and Department of Neurology, 2nd Medical School, Charles University since 2008 Associated professor in Neurology

Publications, lectures, and presentations: over 30 full-length papers in impacted journals up to date over 200 citations over hundred posters and presentations to foreign and Czech conferences

Current research activities: biomarkers of Alzheimer's disease spatial memory mild cognitive impairment

International Memberships: vice-chair of the European Federation of Neurological Societies (EFNS) Scientific panel on dementia and cognitive neurology, in charge of EFNS task force on cerebrospinal fluid biomarkers. leading the EFNS guideline process on Alzheimer disease Member of the EFNS task force on Neuropsychology and EFNS guidelines on Non-AD dementias Member of organizing committee of ADPD 2009 conference Scientific advisory board for ADPD 2011

Clinical Fellowship and courses: 1994 Nevill Hall Hospital, Great Britain, internal medicine 20001 Memory clinic at Queen Square Institute of Neurology, London 2003 Memory disorders unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA December 2007 University of South Florida, Tampa, USA

Important publications: HORT J., O´BRIEN J., GAINNOTTI G., PIRTILA T., POPESCU B., REKTOROVA I., SORBI S., SCHELTENS P. EFNS guidelines for the diagnosis and management of Alzheimer’s disease. EUR J NEUROLOGY 2010 Oct;17(10):123­6–48. doi: 10.1111/j.1468–1331­.2010.03040.x. MARUTA C, GUERREIRO M, De MENDONCA A, HORT J., SCHELTENS P. The use of neuropsychological tests across Europe: the need for a consensus in the use of assessment tools for dementia. EUR J NEUROLOGY 2010 27 Jun. [Epub ahead of print] HORT J., BARTOS A., PIRTTILA T and SCHELTENS P. se of cerebrospinal fluid biomarkers in diagnosis of dementia across Europe, EUR J NEUROLOGY, 2010 Jan;17(1­):90–6. Epub 2009 Jul 29. LACZÓ J, VLCEK K, VYHNALEK M, VAJNEROVA O, ORT M, HOLMEROVA I, TOLAR M, ANDEL R, BOJAR M, HORT J. Spatial navigation testing discriminates two types of amnestic mild cognitive impairment. BEHAV BRAIN RES 2009 Sep 14;202(2):252–9. HORT, Jakub, LACZO, Jan, VYHNÁLEK, Martin et. al. Spatial navigation deficit in amnestic Mild cognitive impairment. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104, MAR 6 2007, No.10, p. 4042–4047 SAKKA, Paraskevi, TSOLAKI, Magda, HORT, Jakub et al. Effectiveness of donepezil in patients with Alzheimer’s disease discontinuing memantine monotherapy. CURRENT MEDICAL RESEARCH AND OPINION, DEC 2007; 23(12):3153–3165 HOŘÍNEK, Daniel, PETROVICKÝ, Pavel, HORT, Jakub et. al. Amygdalar volume and psychiatric symptoms in Alzheimer´s disease: an MRI analysis. ACTA NEUROLOGICA SCANDINAVICA 113, 2006, No.1., 40–45 HOŘÍNEK, Daniel, VARJASSYOVÁ, Alexandra and HORT, Jakub. Magnetic Resonance analysis of Amygdalar volume in Alzheimer's Di­sease. CURRENT OPINION IN PSYCHIATRY, 20, 2007, No. 3, 273–277 REKTOROVA I., RUSINA R., HORT J., MATĚJ R. The degenerative dementias. In: Robert P Lisak, Daniel D Truong, William M Carroll and Roongroj Bhidayasiri. International Neurology, Clinical approach, p. 126– 150, Wiley Blackwell, 2009 HORT J., O´BRIEN J., GAINNOTTI G., PIRTILA T., POPESCU B., REKTOROVA I., SORBI S., SCHELTENS P. Alzheimer’s disease. In: Nils Erik Gilhus, Michael R. Barnes, Michael Brainin. European Handbook of Neurological Management, Volume 1, 2nd Edition. ISBN: 978–1–4051–8533–2, Wiley-Blackwell, October 2010